Wednesday, February 29, 2012

Online Health Expert's Medical News Flash: In a Japanese Study, Thrombin Inhibitor Argatroban Has Been Shown to Inhibit Bone Metastasis of Breast Cancer Cells in Mice.

Breast Cancer Feb. 23, 2012: In an exciting new study done at the Department of Orthopaedic Surgery, Mie University School of Medicine, Tsu, Mie, Japan, published in the Journal Breast Cancer in partnership with The Japanese Breast Cancer Society found Thrombin-inhibitor Argatroban to inhibit Bone Metastasis of Breast Cancer cells via down regulation of Tissue Factor (TF) and Vascular Endothelial Growth Factor (VEGF).

The team of Researchers injected MDA 231 Breast Cancer cells, treated with Thrombin, in the Mice hearts and compared the Test group that was given Argatroban intraperitonially for 28 days with the Control group that received saline and found the number of Bone Metastasis in the Argatroban group to be significantly lower than the saline group (p < 0.05).
Further Reading and Sources:
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Thank you for updating your Medical Knowledge at Online Health Expert.
Dr. Harish Malik.

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