Pancreatic
cancer that took away Apple's CEO Mr. Steve Jobs (Mr. Steven Paul Jobs) is a
particularly difficult cancer to beat. It’s been shown to harbor Stem Cells
that utilize the embryonic pathway (Nodal/Activin Pathway) that is absent in
the adult cells.
This pathway's embryonic ties and their absence in
other tissues have presented a real opportunity to kill pancreatic cancer cells.
It suggests that one could target the molecular pathway without harming other
adult cells. Heeschen's team has already shown that this approach to therapy
does work in mice.
"I don't think the cancer stem cells have any
direct link to embryonic development, rather they are using this developmental
pathway for their uncontrolled self-renewal capacity”, said Christopher
Heeschen of the Spanish National Cancer Research Centre in Madrid.
This approach to treat Pancreatic cancer is being
developed for human use and there are hints that this pathway might have
important role in other forms of cancer such as Breast, Lung and Colorectal
cancers.
"The concept that you can hit cancer stem cells
and tumors will melt away must be abandoned”, Heeschen said. "You have to
treat the entire cancer - the stroma, cancer stem cells and differentiated
cells - as a complex".
Thank
you for updating your medical knowledge at Online Health Expert.
Sincerely,
Dr.
Harish Malik
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